Macrophage abundance in oncocytic thyroid cancer is associated with PD-L1 expression.

ABSTRACT:

Objective

Oncocytic thyroid cancer (OTC) accounts for 3-5% of thyroid cancers. Previously classified as a subtype of follicular thyroid cancer (FTC), OTC has been redefined by the World Health Organization due to its distinct histopathological and molecular features. OTC demonstrates a more aggressive clinical course than other differentiated thyroid cancers, with higher rates of distant metastases and is often refractory to radioactive iodine therapy (RAI). This study investigates the transcriptional profiles and immune populations of OTC and FTC to identify key differences in gene signatures and immune cell populations.

Methods

We conducted a comparative analysis of the transcriptional profiles of OTC (n = 12), FTC (n = 8), and non-neoplastic thyroid tissues

SUBMITTER: Ricarte-Filho JC 

PROVIDER: S-EPMC12508309 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature