The global, regional, and national burden of acute lymphoblastic leukemia, 1990 to 2021: a cross-sectional analysis from the 2021 global burden of disease study.

ABSTRACT:

Background

Acute lymphoblastic leukemia (ALL) remains a major public health challenge, yet its global burden and epidemiological trends are inadequately characterized. This study evaluates the global burden of ALL from 1990 to 2021 and projects trends through 2040. ​​METHODS: Using data from the Global Burden of Disease (GBD) Study 2021, we analyzed prevalence, incidence, mortality, disability-adjusted life years (DALYs), and age-standardized rates (ASRs) for ALL, stratified by time, region, age, and Socio-Demographic Index (SDI). Advanced methods included estimated annual percentage change (EAPC), Joinpoint regression, decomposition and frontier analyses, and Bayesian Age-Period-Cohort (BAPC) modeling to quantify trends, inequalities, and projections.

Results

In 2021, ALL c

SUBMITTER: Yuan C 

PROVIDER: S-EPMC12508354 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature