The effect of SARS-CoV-2 infection on the liver function tests: a systematic review and meta-analysis of observational studies.

ABSTRACT:

Introduction

SARS-CoV-2 infection has been associated with respiratory distress syndrome and hepatic injury. The mechanism of liver injury is not fully understood and may be a combined effect of viral hepatitis, systemic inflammation, gut barrier disruption, microbiome alterations or drug toxicity.

Aim

We carried out a systematic review and meta-analysis to determine whether SARS-CoV-2 infection affects the level of liver-produced molecules: alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyl transferase (GGTP), bilirubin, total protein, albumin, and prothrombin (with INR).

Methods

Ten authors independently searched PubMed and Embase from their inception until 04/03/2021 for observational studies to evaluate whether SARS CoV-2 infection influe

SUBMITTER: Kotfis K 

PROVIDER: S-EPMC12508384 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature