LncRNA LINC02381/miR-133b axis promotes tumorigenesis and predicts survival in pancreatic cancer.

ABSTRACT:

Background

LncRNA LINC02381 has emerged as a promising tumor biomarker; however, its involvement in the pathogenesis of pancreatic cancer remains unexplored at this time. The objective of this study is to elucidate the regulatory effect of LINC02381 in pancreatic cancer and to ascertain its potential prognostic significance.

Methods

The clinical characteristics of the pancreatic cancer patients included were meticulously analyzed, with a total of 112 pancreatic cancer and 75 normal tissue samples collected. Real-time quantitative polymerase chain reaction (RT-qPCR) was applied to detect LINC02381 and miR-133b expression. The proliferative activity of pancreatic cancer cells was verified via in vitro CCK-8 and Transwell assays. The targeting relationship between LINC02381 and

SUBMITTER: He J 

PROVIDER: S-EPMC12508400 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature