CD8 T cell exhaustion-associated LncRNA signature reveals novel molecular subtypes and immune targets in hepatocellular carcinoma.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) presents challenges and opportunities for immunotherapy due to its intricate immune microenvironment. Exhausted CD8 T cells (CD8Tex) are pivotal in this context but are inadequately characterized in HCC.

Methods

We conducted single-cell analysis on the GSE140228 dataset to identify key genes associated with CD8Tex in HCC. Cell communication analysis elucidated strong interactions of CD8Tex with CD8 T cells, dendritic cells (DCs), and monocytes/macrophages.

Results

Pearson correlation analysis using the TCGA-LIHC dataset identified CD8Tex-associated long non-coding RNAs (lncRNAs). Utilizing univariate and multivariate Cox regression analyses, along with LASSO regression to prevent overfitting, we developed a prognostic model in

SUBMITTER: Feng J 

PROVIDER: S-EPMC12508406 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature