Tracing the evolutionary trajectory of Japanese encephalitis virus across hosts and countries.

ABSTRACT: Japanese encephalitis Virus (JEV), the leading cause of epidemic encephalitis worldwide, is widespread across Asia and Australia cycling between vertebrate reservoir hosts and culicine mosquitoes. Change in dominant genotype, epidemics in new regions and re-emergence of dormant genotypes pose major public health concerns. To investigate the prevalent genotypes and their host range, JEV isolates were compiled from NCBI GenBank over a period of eight decades and full-length envelope gene sequences were analyzed. TMRCA analysis confirmed that JEV originated in the Indonesia-Malaysia region and subsequently diversified into multiple genotypes. Intriguing trends in the genotype distribution and the spread of the virus across various hosts and regions were observed. A notable change from GIII to

SUBMITTER: Kishore KJN 

PROVIDER: S-EPMC12508474 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature