Epigenetic Regulation of Ferroptosis in Chronic Kidney Disease: Mechanisms and Implications.

ABSTRACT: Chronic kidney disease (CKD) is a prevalent and progressive condition that leads to renal structural abnormalities and a gradual decline in kidney function. CKD has various etiologies, including diabetes, hypertension, and glomerulonephritis, and is associated with significant morbidity, mortality, and economic burden. Current treatments focus on slowing disease progression and managing complications; however, CKD often progresses to end-stage renal disease, necessitating renal replacement therapy. Therefore, innovative therapeutic approaches are urgently required. Recent studies have highlighted the role of ferroptosis, an iron-dependent form of cell death characterized by lipid peroxidation and oxidative stress, in CKD pathogenesis. Ferroptosis contributes to structural damage and functi

SUBMITTER: Mao ZH 

PROVIDER: S-EPMC12508529 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature