Herbal Medicine for Colorectal Cancer Treatment: Molecular Mechanisms and Clinical Applications.

ABSTRACT: Colorectal cancer (CRC) is one of the most common malignant tumours and is the second leading cause of cancer-related mortality worldwide. Despite the availability of preventative, diagnostic and treatment methods including endoscopic treatment, surgical intervention, radiotherapy, biologics, salvage therapy and immunotherapy, the mortality rate associated with CRC remains alarming. Consequently, there is a pressing need to search for medicines for the treatment of CRC. Phytomedicines have been shown to suppress the proliferation and metastasis of CRC through various mechanisms, including immune regulation, modulation of gut microbiota, targeting of stem cells, macrophage polarisation, glycolysis, ferroptosis induction, modulation of extracellular vesicles, activation of mitochondria-induc

SUBMITTER: Su Z 

PROVIDER: S-EPMC12508688 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature