Investigation of the Effect of Isotonic Drinks on Quantitative MRI Markers of the Liver and Spleen.

ABSTRACT: Quantitative MRI markers of the liver are attractive diagnostic tools of metabolic dysfunction-associated steatotic liver disease (MASLD). However, T1$$ {\mathrm{T}}_1 $$ measurements are confounded by physiological factors, such as hydration. The aim of this study is to evaluate the dynamic effects of hydration with isotonic drinks on quantitative MRI measurements of the liver in healthy male individuals. Shortened modified Look-Locker inversion recovery-based (shMOLLI) T1$$ {\mathrm{T}}_1 $$ , T2*$$ {{\mathrm{T}}_2}^{\ast } $$ , proton density fat fraction (PDFF), apparent diffusion coefficient (ADC), stiffness, and volume of the liver, as well as shMOLLI T1$$ {\mathrm{T}}_1 $$ and volume of the spleen were measured repeatedly in six healthy male volunteers at 3 T after ingesting 0.5, 1.

SUBMITTER: Pittas NN 

PROVIDER: S-EPMC12508728 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature