Genome-wide association study of chlamydia reinfection in African American women.

ABSTRACT:

Background

Chlamydia trachomatis (Ct) is a bacterium that causes chlamydia, the most diagnosed bacterial sexually transmitted infection (STI) in the world. In the U.S., chlamydia is most prevalent among non-Hispanic African American (AA) individuals, implying substantial racial disparity. Despite prevention and control efforts, reinfection is common, suggesting that some individuals have insufficient protective immunity to Ct. To better understand the genetically mediated risks of chlamydia reinfection, we sought to identify genetic loci associated with reinfection using a Genome-Wide Association Study (GWAS) approach.

Method

We performed GWAS in 300 AA women with versus without chlamydia reinfection based on Ct testing done about 3 months after chlamydi

SUBMITTER: Tiwari HK 

PROVIDER: S-EPMC12508776 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature