Neutrophil dynamics in surgical wounds - A novel role of interleukin-7.

ABSTRACT: Postoperative pain and consequently chronic postsurgical pain remain a significant burden among patients. While neutrophilic granulocytes (neutrophils) are known to play a critical role in wound healing, their precise contribution to pain modulation is not fully understood. The neurotrophin nerve growth factor (NGF), released by fibroblasts and immune cells following injury, is an early mediator of pain development. A companion paper demonstrated that NGF administration to axons of cultured sensory neurons in microfluidic chambers induces upregulation of Il7, encoding interleukin-7 (IL-7). However, its role in neutrophil dynamics within surgical wounds remains broadly unclear. In a murine model of laparotomy, we observed that IL-7 was expressed at wound sites and co-localized with s

SUBMITTER: Biesold A 

PROVIDER: S-EPMC12508816 | biostudies-literature | 2025 Jul-Dec

REPOSITORIES: biostudies-literature