Metabolomic determinants of sarcopenia incidence: A 14-year prospective study of 33,797 participants.

ABSTRACT:

Objectives

Sarcopenia, an age-related loss of skeletal muscle mass and strength, increases the risk of adverse health outcomes and socioeconomic burden; however, the metabolic causes of sarcopenia are unclear. This study investigated the association between plasma metabolites and incident sarcopenia and evaluated their predictive value for the incidence of sarcopenia.

Methods

This prospective cohort study included 33,797 participants aged 40-69 years from the UK Biobank who were free of sarcopenia and had plasma metabolomic data available. Plasma metabolite levels, including amino acids, fatty acids, lipid/lipoprotein subclasses, creatinine, and glycoprotein acetyls, were measured using nuclear magnetic resonance-based profiling. Incident sarcopenia was defined using the ICD

SUBMITTER: Kim HN 

PROVIDER: S-EPMC12508829 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature