Different mechanisms of axitinib and diazepam antiseizure action in pentylenetetrazol-induced kindling model.

ABSTRACT:

Introduction

This study intended to assess the histomorphology characteristics of hippocampal structures and determine the severity of seizures after treatment with the tyrosine kinase B inhibitor axitinib and diazepam in fully developed and postponed period in PTZ-kindled rats.

Methods and materials

Wistar rats were given PTZ for 21 days until fully developed convulsions were achieved. Two protocols were explored: assessment of seizures immediately after the completion of the kindling (early kindling) and after a two-week post-kindling PTZ-free period. Treatment with axitinib and diazepam was performed before early and postponed kindling seizures assessment, with the consequent collection of brains for histomorphology.

Results

Axitinib and diazepam effectively reduce

SUBMITTER: Godlevsky LS 

PROVIDER: S-EPMC12508834 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature