CX3CL1/CX3CR1 involved modulation of microglial activation and eosinophilic meningoencephalitis in angiostrongyliasis.

ABSTRACT: Angiostrongylus cantonensis typically infects humans through the ingestion of contaminated food or water containing the larvae. A. cantonensis is a neurotropic parasitic nematode that causes eosinophilic meningitis in humans. Upon invasion of the CNS, A. cantonensis larvae elicit a pronounced immune response, rapidly activating microglia and triggering the release of pro-inflammatory cytokines. The CX3CL1/CX3CR1 axis has been implicated in maintaining chronic microglial activation, which could exacerbate neuroinflammation. However, the precise role of this signaling pathway in angiostrongyliasis remains poorly understood. This study aims to elucidate the mechanistic role of CX3CL1/CX3CR1 signaling in microglial activation and neuronal degeneration in CNS infections cau

SUBMITTER: Lai SC 

PROVIDER: S-EPMC12508840 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature