Design, Synthesis, and Computational Studies of Novel <i>N-</i>(Substituted phenyl)-3-(5-((naphthalen-2-yloxy)methyl)-4-phenyl‑4<i>H</i>‑1,2,4-triazol-3-ylthio)acetamides as Potent Acetylcholinesterase Inhibitors.

ABSTRACT: The current studies elaborate the synthesis of some new N-(substituted phenyl)-3-(5-((naphthalen-2-yloxy)-methyl)-4-phenyl-4H-1,2,4-triazol-3-ylthio)-acetamides (8a-8h). This novel synthesis was accomplished by a well-explained protocol and structural corroboration of derivatives with the help of infrared, electron ionization mass spectrometry, and ¹H nuclear magnetic resonance (NMR) and ¹³C NMR spectral techniques. The in vitro inhibitory potential of newly synthesized acetamides was evaluated against acetylcholinesterase enzyme, and it was explored that all the compounds showed relatively comparable potential as compared to donepezil (IC₅₀ = 0.454 ± 0.076) used as a standard. Among the unique group of these triazo

SUBMITTER: Ayub M 

PROVIDER: S-EPMC12508928 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature