Unveiling the Therapeutic Potential: A Peptide Drug Conjugate's Influence on Transcription and Translation in Ocular Fibrosis Modulation.

ABSTRACT: Fibrosis is a major challenge in glaucoma management, particularly following surgical interventions like trabeculectomy. In this study, we explored the therapeutic potential of a fibrosis-modulating peptide (VRF2019) and its mitomycin conjugate by evaluating their transcriptomic impact on primary Tenon fibroblast cells isolated from post-trabeculectomy tissues. To the best of our knowledge, this is the first comprehensive transcriptomic mapping of glaucoma-associated fibrotic fibroblasts, incorporating targeted drug delivery mechanisms. Fibroblasts were subjected to three conditions: Control (untreated), peptide treatment, conjugate treatment, and gene expression changes were analyzed through pairwise comparisons. Peptide-treated cells exhibited dysregulation in 231 transcripts, whereas co

SUBMITTER: Suresh Babu J 

PROVIDER: S-EPMC12508960 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature