Intestinal inflammation induces glymphatic remodeling, priming early neurodegenerative signals in male mice.

ABSTRACT:

Introduction

Inflammatory bowel disease triggers extraintestinal manifestations, including in the central nervous system (CNS). However, the direct impact of peripheral inflammation on the CNS is largely unknown.

Methods

Using a mouse model of colitis with pain and anxiety-like behavior, we investigated the intricate pathogenic link between colonic inflammation, disruptions in circadian rhythmicity and impaired glymphatic circulation.

Results

By in vivo magnetic resonance imaging, we observed a derangement of brain fluid dynamics, with a significant enlargement of the cerebral lateral ventricles and waste deposition within the brain parenchyma. Proteomics revealed changes in cerebrospinal fluid (CSF) composition, enriched in proteins related to inflammation, immune re

SUBMITTER: Ciampi C 

PROVIDER: S-EPMC12509038 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature