Opuntia ficus-indica fruit consumption improves insulin resistance in mice with diet-induced obesity.

ABSTRACT:

Background

Obesity induces various co-morbidities including insulin resistance. Opuntia ficus-indica fruit (OFIF) is rich in various beneficial compounds with antioxidant and anti-inflammatory properties. The present study evaluated the efficacy of OFIF supplementation to counteract obesity-induced insulin resistance in comparison with an euglycemic agent, chromium picolinate (CrPi), in high-fat-diet (HFD)-fed mice. Molecular investigations associated with the observed effects as well as the evaluation of OFIF impact on the composition of gut microbiota in HFD mice were also carried out. Glucose metabolic parameters, oxidative stress and inflammation-related biomarkers were analysed in liver and adipose tissue of HFD, HFD + OFIF and HFD + CrPI mice.

Results

OFIF supplementat

SUBMITTER: Terzo S 

PROVIDER: S-EPMC12509048 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature