Kinase suppressor of Ras 1 (KSR1) promotes liver carcinogenesis via activation of the RAS/RAF/MEK/ERK signaling pathway.

ABSTRACT:

Background & aims

Mutations in the RAS and RAF genes are frequently observed in various human cancers, leading to persistent activation of the RAS/RAF/MEK/ERK signaling pathway and driving tumorigenesis. Intriguingly, hepatocellular carcinoma (HCC) reveals rare mutations in RAS and RAF, despite frequent activation of the RAS/RAF/MEK/ERK signaling. Here, we identify kinase suppressor of Ras 1 (KSR1) as a pivotal player in pathway activation and tumorigenesis in the liver.

Methods

Gene expression data from human cancers were analyzed using publicly available databases. HCC cell lines stably expressing KSR1 were established to evaluate RAS/RAF/MEK/ERK signaling activity. Liver cancer was induced in C57BL/6 male mice via hydrodynamic tail vein injection. Tumor-bear

SUBMITTER: Moon H 

PROVIDER: S-EPMC12509110 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature