Evaluation of Factors Impacting Nicotine Permeation in Oral Nicotine Pouch Products.

ABSTRACT: In recent years, oral nicotine pouches or "tobacco-free nicotine pouches" have emerged as potential reduced-risk alternatives to traditional tobacco products. The aim of this research was to evaluate and further develop laboratory tools to measure the nicotine release rate from nicotine pouches and its permeation through the oral mucosa. For this, we evaluated the nicotine dissolution rate and buccal permeability of three nicotine pouch brands: Zyn, Velo, and Dryft nicotine pouches. Dissolution testing was conducted using the United States Pharmacopeia 4 (USP-4) apparatus and an in-house developed sinker method in three different artificial salivas, one laboratory-made saliva (Buffer saliva) and two commercially available salivas (Salivea and Orthana). Zyn nicot

SUBMITTER: Li XS 

PROVIDER: S-EPMC12509121 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature