Clinical pharmacist-led Antimicrobial Stewardship under volume-based procurement: a retrospective quasi-experimental study on rational use and resistance control.

ABSTRACT:

Background

Antimicrobial resistance (AMR) is a global health crisis exacerbated by policies like China's Volume-Based Procurement (VBP), which may inadvertently increase antimicrobial overuse. This study evaluates a clinical pharmacist-led Antimicrobial Stewardship (AMS) program with prospective audit for special-restricted antimicrobials under VBP.

Methods

A retrospective quasi-experimental interrupted time-series analysis compared pre-intervention (2022) and post-intervention (2023-2024) data at Tongji Hospital, a tertiary hospital in Wuhan, China. Key metrics included Antimicrobial Use Density (AUD), prescription rationality, antimicrobial costs, and multidrug-resistant infection rates.

Results

The intervention significantly improved prescription appropriateness fo

SUBMITTER: He Y 

PROVIDER: S-EPMC12509153 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature