Novel Pyrrolidine-Based Pyrazolines as α‑Glucosidase Inhibitors: Microwave-Assisted Synthesis, Antidiabetic Activity, <i>In Silico</i> ADMET Prediction, Molecular Docking, and Molecular Dynamics Simulations.

ABSTRACT: Due to their unique properties, small multitargeted drugs containing a fluorinated aromatic moiety and nitrogenous heterocycles are widely available on the market. Considering the pharmacological significance of organofluorine and heterocyclic compounds, in this study, we synthesized a series of pyrazoline derivatives (14-27) containing a pyrrolidine moiety and substituted them with a fluorine atom or a fluorine-containing (-CF₃ or -OCF₃) group at different positions. Also, the antidiabetic activities of new pyrazolines were screened by in vitro α-glucosidase and α-amylase activity assays in order to investigate their potential use in the treatment of Diabetes Mellitus, one of the most common and rapidly spreading diseases of today. The findings of this

SUBMITTER: Kursun Aktar BS 

PROVIDER: S-EPMC12509173 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature