Anterior Insula Drives Progressive Structural Brain Network Atrophy in the Behavioural Variant of Frontotemporal Dementia.

ABSTRACT: The behavioural variant of frontotemporal dementia (bvFTD) is a younger-onset dementia syndrome characterised by early atrophy of frontoinsular cortices, manifesting in profound socioemotional disturbances. Converging evidence from correlational, data-driven, and computational approaches indicates large-scale network degeneration in bvFTD. While the insula is consistently implicated, it remains unclear whether insular atrophy causally impacts progressive large-scale structural network alterations in bvFTD. Eighty-two patients with clinically probable bvFTD were classified as very mild/mild (n = 35), moderate (n = 30), and severe (n = 17) using the CDR plus NACC FTLD. Grey matter volume comparison between the entire bvFTD group and a healthy control group matched for age and education ident

SUBMITTER: Chen T 

PROVIDER: S-EPMC12509179 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature