Waveguide Spectroscopy for Differentiation of Bacteria.

ABSTRACT: Mid-infrared spectroscopy allows precise and label-free molecular fingerprinting of the chemical composition of bacteria. Waveguide spectroscopy promises several benefits compared to conventional ATR-FTIR spectroscopy, such as higher sensitivity and the potential for miniaturization. In this study we demonstrate mid-infrared spectroscopy of lipopolysaccharides and intact bacteria cells on a diamond waveguide with quantum cascade lasers as light source. The diamond waveguide with aluminum nitride as undercladding was tuned with a thin silicon film to specifically target the polysaccharide part of the mid-infrared spectrum (1200-1050 cm^-1). It was shown to have good performance when measuring in aqueous solutions, with an order of magnitude sensitivity enhancement compared to conv

SUBMITTER: Angelsten A 

PROVIDER: S-EPMC12509186 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature