Blood pressure at age 40 and key features of cerebral small vessel disease at age 70: data from the ACE 1950 Study.

ABSTRACT:

Background

The separate effects of systolic (SBP) and diastolic blood pressure (DBP) on cerebral small vessel disease (cSVD) development needs elucidation. We investigated the association between SBP and DBP at age 40 and two selected brain magnetic resonance imaging (MRI) features of cSVD (lacunes and white matter hyperintensities [WMHs]) at age 70 in a general Norwegian population cohort.

Methods

We included individuals from the Akershus Cardiac Examination (ACE) 1950 Study (2012-2015) who had previously participated in the Age 40 Program (1990-1993). A random subset of participants with SBP in the categories of non-elevated (< 120 mmHg), high elevated (130-139 mmHg) or hypertension (≥ 140 mmHg) at age 40 were invited to perform brain MRI for assessment of cSVD (lacunes an

SUBMITTER: Walle-Hansen MM 

PROVIDER: S-EPMC12509344 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature