Composition of carotid plaques differs between Chinese and US patients: a histology study.

ABSTRACT:

Background

The clinical manifestations of cerebrovascular disease are known to differ between the Chinese and United States (US) populations as do the plaque features on imaging.

Objectives

The aim of this study was to investigate and compare the histological features of excised carotid plaques from Chinese and US patients.

Methods

Carotid endarterectomy specimens collected from two prospective studies were included. The entire plaque was serially sectioned (10-µm thickness) at 0.5-1 mm intervals. Hematoxylin and eosin staining and Mallory's trichrome staining were performed. The morphology and components of the plaques were measured and compared between the two groups.

Results

A total of 1152 histological sections from 75 Chinese patients and 1843 sections fro

SUBMITTER: Cao J 

PROVIDER: S-EPMC12509396 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature