Modeling Temporal Summation and Conditioned Pain Modulation in Individuals With and Without Chronic Pain.

ABSTRACT:

Objectives

Although significant progress has been made in recent years in the field of pain modulation, information regarding patients' pain modulation profiles remains largely research-bound and is not yet easily accessible in clinical settings. The aim of this study was to develop and validate a model for estimating pain modulation profiles-including temporal summation of pain (TSP) and conditioned pain modulation (CPM)-using easily accessible measures.

Methods

This study included 347 pain-free individuals and 108 with chronic pain. TSP was induced through tonic heat pain stimulations, whereas CPM was evaluated using pressure pain thresholds (CPM-PPT) and tonic heat pain stimulations (CPM-HPS) as test stimuli, with the cold pressor test as the conditioning stimulus. Indepe

SUBMITTER: Vincenot M 

PROVIDER: S-EPMC12509438 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature