Evaluating the Aqueous Stability of Alkyl-/Aryl-Hydrosilanes by NMR Spectroscopy and GC-MS.

ABSTRACT: Hydrosilanes are commonly used as reducing agents or as synthetic precursors for silanols. However, the incorporation of hydrosilanes as carbon bioisosteres is underexplored. In this study, the hydrolytic stability of ten variably substituted hydrosilanes-including monoaryl, monoalkyl, diaryl, dialkyl, alkyl aryl, triaryl, trialkyl, dialkyl aryl, and alkyl diaryl silanes-is investigated using five complementary methods, including ¹H-NMR time-lapse and GC-MS experiments, at neutral pH. The ¹H-NMR time-lapse experiments suggest that monoaryl and monoalkyl silanes are susceptible to hydrolysis, as evidenced by 31% and 22% reduction in starting material, respectively, over 24 h. Other investigated silanes are resistant to hydrolysis in these solvent systems for at least 2

SUBMITTER: Azam F 

PROVIDER: S-EPMC12509473 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature