How Sodium Dodecyl Sulfate Micelles Affect the Coordination and Peroxidase-Like Activity of the Hemin-Aβ16 Complex.

ABSTRACT: Alzheimer's disease is an age-related neurodegenerative disorder and the main cause of dementia in the elderly. The accumulation of metal ions, including iron-heme, their interaction with amyloid-β (Aβ) peptides and their ability to catalyze reactive oxygen species formation significantly contribute to the pathogenesis of the disorder. These factors are highly dependent on the surrounding environment, whether intracellular, extracellular, or membrane-associated. In this study, the interaction between heme and Aβ within a membrane-mimicking system using sodium dodecyl sulfate is investigated. UV-vis and circular dichroism data indicate that the heme/Aβ complex can be sequestered within the micelle, leaving part of Aβ largely exposed at the surface. The presence of the micellar environment s

SUBMITTER: Bacchella C 

PROVIDER: S-EPMC12509477 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature