First-in-human e-Flash radiotherapy using a modified conventional C-arm linear accelerator.

ABSTRACT:

Background

The FLASH effect is considered being the widening of the therapeutic window at (ultra-)high dose rates due to sparing of normal tissues while preserving tumor response. Our goal was to provide first data on the safety in treating a patient using a conventional linear accelerator converted to deliver 9 MeV UHDR electron beams in the research setting.

Material & methods

A conventional Varian TrueBeam linac was converted in the research setting to become capable of delivering 9 MeV UHDR electron beams. A phase I trial protocol was approved by the local authorities (NCT06549439). One patient with ≥ 1 melanoma (sub)-cutaneous lesion(s) was treated with 3x 9 Gy. The first two fractions were applied via e-Flash and the third via conventional electrons.

Results

Her

SUBMITTER: von der Grun J 

PROVIDER: S-EPMC12509727 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature