Chronic stress-induced downregulation of MFN1 contributes to fatty liver in chickens.

ABSTRACT:

Background

Chronic stress is a major contributor to Fatty Liver Syndrome (FLS) in fast-growing broilers, leading to physiological dysfunctions that compromise growth and immune response. This study aimed to investigate the effects of chronic stress on hepatic lipid metabolism and mitochondrial dynamics in broilers.

Method

Forty 1-day-old male AA broilers were randomly allocated into two groups (n = 20): control (CON) and corticosterone-treated (CORT). From day 38, the CORT group received twice-daily subcutaneous injections of CORT (4 mg/kg/day) for 7 days to simulate in vivo chronic stress model. The loss-of-function approaches in cell culture models were also applied to investigate the role of MFN1 in CORT-induced mitochondrial dysfunction.

Results

Chro

SUBMITTER: Zhang K 

PROVIDER: S-EPMC12509737 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature