Biopolymer-based biomaterial containing gold nanoparticles-bioactive glass for bone regeneration in a complicated tibial fracture in a dog: a case report.

ABSTRACT: A revision surgery for a tibial fracture in a dog, complicated by a secondary fracture site, implant migration, breakage, and bending of the initial implants, was described. After diaphyseal tibial osteotomy, the resulting gaps and bone defects were filled with the alginate-pullulan-bioactive glass-gold nanoparticles (Alg-Pll-BGAuSP) composite. The objective of applying this composite was to stimulate cell proliferation, based on its demonstrated bioactive effect, biodegradability, biocompatibility, and osteoinductive properties. The regenerative process was monitored both clinically and radiologically, with the aim of achieving an improved outcome and enhancing the welfare of the animal. At 12 weeks postoperatively, the implants were removed, and the limb resumed its original function. Th

SUBMITTER: Astilean AN 

PROVIDER: S-EPMC12509738 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature