Impact of COVID-19 pandemic on cognitive decline in community-dwelling older adults in Shanghai: a longitudinal study from 2010 to 2024.

ABSTRACT:

Background

In 2022, the rapid spread of the highly transmissible Omicron variant precipitated a dramatic surge in infections and a subsequent societal shutdown in Shanghai. It offers the opportunity to examine the impact of COVID-19 pandemic on cognitive decline among community-dwelling older adults.

Methods

The Shanghai Aging Study enrolled 3792 community residents aged ≥ 50 from 2010 to 2012 in central Shanghai. Demographics, medical history, ApoE genotyping, and plasma phosphorylated tau 217 (p-tau217), phosphorylated tau 181 (p-tau181), and neurofilament light chain (NfL) were collected at baseline. Cognitive function assessment and MRI scans were conducted at baseline and follow-up visits from 2014 to 2024. Study periods were defined as Wave 1 (Jan.2010-Dec.2012, baseli

SUBMITTER: Zhou X 

PROVIDER: S-EPMC12509743 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature