ARHGAP10 is a novel microtubule-associated protein that regulates the resorption activity of osteoclasts.

ABSTRACT: Adult-bone homeostasis is maintained through the reciprocal actions of osteoclasts and osteoblasts, which, respectively, resorb and deposit new bone. Excessive osteoclast activity leads to bone loss and contributes to conditions like osteoporosis. Osteoclasts form a specialized adhesion structure called the actin ring that is crucial for bone resorption and relies on both the actin and the microtubule cytoskeletons. Our previous studies identified the β-tubulin isotype TUBB6 as a regulator of actin ring dynamics essential for osteoclast function, and found ARHGAP10, a negative regulator of the GTPases CDC42 and RHOA, as a potential mediator of TUBB6 function. Here we show that ARHGAP10 is a novel microtubule-associated protein critical for osteoclast function. ARHGAP10 directly binds micro

SUBMITTER: Jentschel L 

PROVIDER: S-EPMC12509757 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature