Unveiling the "Dark Matter" of platelet involvement in tumor microenvironment.

ABSTRACT: Platelets are well-known for their functions in blood clotting and vascular repair. However, in recent years, the regulatory role of platelets in the occurrence and development of malignant tumors has received significant attention. While extensive research has been conducted on the regulation of tumors by circulating platelets in peripheral blood, there is a lack of coherence and continuity among these studies. The tumor microenvironment encompasses the intricate network of cellular and acellular elements that surround and interact with tumor cells, creating a supportive ecosystem for their survival and growth. It plays a crucial role in the initiation and progression of tumors. Similar to dark matter in the universe, platelets, as tiny and enigmatic entities, play an essential role in tu

SUBMITTER: Zhang P 

PROVIDER: S-EPMC12509771 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature