Designing and Evaluating Bayesian Advanced Adaptive Randomised Clinical Trials: A Practical Guide.

ABSTRACT: Advanced adaptive randomised clinical trials are increasingly used. Compared to their conventional counterparts, their flexibility may make them more efficient, increase the probability of obtaining conclusive results without larger samples than necessary, and increase the probability that individual participants are allocated to more promising interventions. However, limited guidance is available on designing and evaluating the performance of advanced adaptive trials. Here, we summarise the methodological considerations and provide practical guidance on the entire workflow of planning and evaluating advanced adaptive trials using adaptive stopping, adaptive arm dropping, and response-adaptive randomisation within a Bayesian statistical framework. This comprehensive practical guide covers

SUBMITTER: Granholm A 

PROVIDER: S-EPMC12509790 | biostudies-literature | 2025 Nov-Dec

REPOSITORIES: biostudies-literature