Investigating genetic, antigenic, and structural diversity in the <i>Neisseria gonorrhoeae</i> outer membrane protein, PorB: implications for vaccine design.

ABSTRACT: Vaccines targeting Neisseria gonorrhoeae are needed to reduce disease burden and help address the problem of antimicrobial resistance, with an understanding of relationships between gonococcal genetics and molecules influencing diversity, infection, and the immune response essential for developing effective vaccine formulations. Whole-genome sequence data can be used to investigate these relationships among thousands of gonococcal isolates, allowing the study of antigenic diversity on a population scale. Such analyses typically examine antigenic diversity occurring in complete protein sequences, generating mean diversity indices and phylogenetic analyses that can inform on vaccine potential; however, to detect and measure the immune responses elicited, epitope characterization withi

SUBMITTER: Harrison OB 

PROVIDER: S-EPMC12509796 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature