Association between immune cells and membranous nephropathy: a two-sample Mendelian randomization study.

ABSTRACT:

Introduction

Multiple studies have indicated that immune cells play a significant role in the occurrence and development of membranous nephropathy (MN). However, the causal relationship between the two has not been fully established. To further investigate this, we employed a Mendelian randomization (MR) study design.

Material and methods

Genetic instrumental variables for immune cells were sourced from an extensive genome-wide association study (GWAS). MN summary statistics, involving 2,150 cases and 5,829 controls, were obtained from a separate GWAS. The primary analysis employed the inverse-variance weighted (IVW) method. To explore reverse causation, a reverse MR analysis was undertaken. Rigorous sensitivity analyses were conducted to ensure the resilience and reliabilit

SUBMITTER: Hou C 

PROVIDER: S-EPMC12509805 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature