Impact of lipid-lowering drug targets on genetic associations with diabetic retinopathy.

ABSTRACT:

Introduction

Lipid metabolism is pivotal in diabetic retinopathy (DR) development. Nevertheless, the relationship between lipid-lowering drugs and the risk of DR remains a topic of debate. This study employed Mendelian randomization (MR) to investigate the potential effects of pharmacological lipid-lowering targets on DR and to clarify the causal association between blood lipid characteristics and DR.

Material and methods

The data comprised genetic variations related to lipid traits and genetic variations associated with lipid-lowering drug targets obtained from the Global Lipid Consortium. Total DR, non-proliferative DR (NPDR), and proliferative DR (PDR) were sourced from the Finnish R9 database. Lipid-lowering drug targets were tested using inverse variance-weighted MR (IV

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12509816 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature