FBAT DAP-G: fine-mapping of genetic associations in family-based studies using the Deterministic Approximation of Posteriors algorithm.

ABSTRACT:

Motivation

Family-based study designs enable genetic association analyses that are robust against population stratification and admixture. The Family-Based Association Test (FBAT) framework extended and generalized the Transmission Disequilibrium Test concept for trios (affected offspring and their parents) to general pedigrees, arbitrary phenotypes, and multi-variant analyses. Following the successful identification of disease susceptibility loci in classical family studies, FBAT approaches can be a valuable tool in modern large-scale biobanks that contain significant proportions of related individuals, often with heterogeneous genetic ancestries. However, recent methods for established downstream analyses, such as statistical fine-mapping, are primarily tailored towards genetic a

SUBMITTER: Hecker J 

PROVIDER: S-EPMC12509871 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature