The causal effects of placental weight on atherosclerotic cardiovascular disease: a Mendelian randomization and mediation analysis.

ABSTRACT:

Introduction

Previous studies have linked placental weight (PW) to cardiovascular diseases, but the causality and potential mediators underlying this relationship are still unknown.

Material and methods

We conducted Mendelian randomization (MR) analysis via summary statistics from genome-wide association studies (GWAS), including PW adjusted for sex, 21 candidate mediators and atherosclerotic cardiovascular disease (ASCVD), which includes coronary heart disease (CHD) and ischemic stroke (IS). Two-step MR was employed to identify and assess the mediation and proportion of potential mediators in the association between PW and ASCVD. Additionally, we conducted a repeated analysis using PW adjusted for gestational age and sex.

Results

Univariable MR (UVMR) analysis reveal

SUBMITTER: Chen D 

PROVIDER: S-EPMC12509873 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature