Sleep disturbances and heart failure: observational study and Mendelian randomization study.

ABSTRACT:

Introduction

Sleep disturbances are prevalent among patients with heart failure (HF) and may trigger acute exacerbations of the condition. However, the causal relationship between sleep disturbances and HF remains uncertain. This study aimed to explore the association and potential causal relationship between sleep disturbances and HF.

Material and methods

Observational study: NHANES data (2005-2008) involving 10,432 participants. Sleep disturbances defined as insomnia, sleep disorders, difficulty falling asleep, trouble sleeping, and nocturnal awakening. Mendelian randomization (MR) study: Genetic variants linked to sleeplessness were obtained from GWAS datasets. MR two-sample analysis was conducted using summary statistics from sleeplessness and HF GWASs.

Results

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SUBMITTER: Wang J 

PROVIDER: S-EPMC12509875 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature