Genotype-matched recombiant inactivated Newcastle disease virus vaccine confer protection against genotype Ⅻ challenge in geese with maternal antibodies.

ABSTRACT: The majority of Newcastle disease virus (NDV) strains circulating in China, which exhibit a tendency toward increased virulence, are from genotype Ⅻ infections obtained from waterfowl. Based on our previous findings, the genotype Ⅻ strain E115 was non-pathogenic in geese but induced notable clinical symptoms in chickens without mortality. However, in recent years, we isolated the genotype Ⅻ strain E117 from dead geese and confirmed its lethality in geese through animal regression tests. Genotype-matched vaccination has been proposed as a potential solution. In this study, two NDV vaccination strains, mE115 and mE117, were rescued and evaluated for their resistance to wild-type virus attacks. In vivo analysis revealed that compared with that of the commercial vaccine group, the mE117, and m

SUBMITTER: Ren J 

PROVIDER: S-EPMC12510025 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature