SESTD1 as a potential prognostic biomarker associated with tumor aggressiveness and immune infiltration in hepatocellular carcinoma.

ABSTRACT:

Background

Hepatocellular Carcinoma (HCC) is one of the most prevalent forms of malignancies worldwide, with a low overall survival rate and limited treatments. SESTD1 is upregulated in a variety of cancers and may serve as a potential prognostic indicator and therapeutic target. However, the expression pattern and functional relevance of SESTD1 in HCC are still unknown.

Methods

SESTD1 expression and its prognostic value in HCC were evaluated by parsing multiple databases, including the Cancer Genome Atlas (TCGA), GEO databases, and Kaplan-Meier (KM) plotter. Gene Ontology (GO) and Gene Set Enrichment Analysis (GSEA) were conducted to investigate the potential biological functions and regulatory pathways of SESTD1. The relationship between SESTD1 expression and immune-infilt

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12510035 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature