Association Between Lithium Use and Periprosthetic Fracture After Total Hip Arthroplasty.

ABSTRACT:

Background

Periprosthetic fracture (PPFx) is a devastating complication following total hip arthroplasty (THA), with concern for higher risk in osteoporotic patients. Lithium is associated with higher bone mineral density, and has emerged as a potential low-cost, widely available method for preventing fractures, promoting fracture healing, and improving implant osseointegration. This study investigated the association between lithium use and risk of PPFx following THA.

Methods

Retrospective review of the PearlDiver Mariner Patient Claims Database was performed, querying all patients who underwent THA for osteoarthritis from 2010 to 2022. Lithium-use patients were those who filled lithium prescriptions for at least 90 days before and 90 days after THA. These patients were pro

SUBMITTER: Rahman R 

PROVIDER: S-EPMC12510077 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature