Cytosolic Peroxiredoxin <i>TSA1</i> Influences Acetic Acid Metabolism and pH Homeostasis in Wine Yeasts.

ABSTRACT: Acetic acid is a key metabolite in yeast fermentation, influencing wine quality through its role in volatile acidity. In Saccharomyces cerevisiae, acetic acid production involves aldehyde dehydrogenases, primarily Ald6p during fermentation and Ald4p under respiratory conditions. However, the regulatory mechanisms of these enzymes throughout fermentation and how they differ in commonly used strains remain partially unclear. This study explores cytosolic peroxiredoxin Tsa1p as a novel regulator of acetic acid metabolism. TSA1 gene deletion revealed strain-dependent effects on acetic acid metabolism and tolerance, showing reduced production and enhanced consumption in the laboratory media. Under respiration, Ald4p-driven acetic acid production, which raises extracellular pH, was

SUBMITTER: Garrigos V 

PROVIDER: S-EPMC12510144 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature