May Sulfites in Wine Affect Gut Microbiota? An In Vitro Study of Their Digestion and Interplay with Wine Polyphenols.

ABSTRACT: Sulfites are widely used in the wine industry, but their human health effects remain debated. This study is the first to investigate the interaction between wine sulfites and gut microbiota under simulated gastrointestinal conditions. Using the simgi model, red and synthetic wines─with and without SO₂ (200 mg/L)─underwent gastrointestinal digestion and colonic fermentation with fecal microbiota from three healthy donors (n = 3). SO₂-treated wines slightly modified gut microbiota composition, decreasing beneficial bacteria like Bacteroides and Ruminococcus, while increasing Coprococcus and pro-inflammatory Escherichia/Shigella, although the overall microbiome of each individual seems to condition its resilience toward SO_2<

SUBMITTER: Relano de la Guia E 

PROVIDER: S-EPMC12510145 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature