Subcortical resting state functional connectivity as a neural marker of first onset internalizing disorder in high-risk youth.

ABSTRACT:

Background

Research has linked individual differences in resting state functional connectivity (RSFC) of subcortical brain regions to internalizing disorders, but little research has examined if these changes are pre-morbid risk factors. This study examined individual differences in subcortical RSFC as risk factors for the first lifetime onset of an internalizing disorder in youth at familial risk.

Methods

Participants (n = 93) were adolescents with a parental history of internalizing disorders, but with no such history themselves. Youth completed resting state fMRI scans, as well as the MINI-Kid and the Youth Self Report internalizing symptoms scale at baseline. The MINI-Kid was completed again at 9 or 18-month follow-up to assess onset of internalizing disorders. Seed-to-w

SUBMITTER: Pawlak M 

PROVIDER: S-EPMC12510205 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature