Endothelial SR-B1 is dispensable for thermogenesis but promotes selective cholesterol uptake in brown adipose tissue.

ABSTRACT: In an interplay with parenchymal cells of metabolically active organs, such as heart and adipose tissues, vascular endothelial cells are important for the regulation of nutrient uptake and organ-specific energy metabolism. Based on high expression of the scavenger receptor class B type I (SR-B1) in capillary endothelial cells of white adipose tissue and brown adipose tissue (BAT), we proposed a functional role for this receptor in lipid handling and adaptive thermogenesis. To address this hypothesis, we generated mice with an endothelial-specific KO of SR-B1 and performed metabolic turnover and indirect calorimetry studies in response to environmental cues, such as cold exposure and high-fat diet feeding. Compared with control littermates, endothelial-specific SR-B1 KO mice had substantial

SUBMITTER: Hurkmans KM 

PROVIDER: S-EPMC12510209 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature