Effect of carperitide on mortality and ANP levels in acute heart failure: A systematic review and meta-analysis.

ABSTRACT:

Background

Acute heart failure (AHF) is a common and severe condition associated with high morbidity and mortality. Carperitide, a recombinant human atrial natriuretic peptide, has been widely used in Japan for managing AHF. However, its effectiveness in improving clinical outcomes such as mortality rates remains unclear, with conflicting evidence from studies.

Methods

A systematic review and meta-analysis were conducted on studies comparing carperitide with placebo in AHF patients. Six studies including randomized and observational studies involving 30,665 patients were included, with primary outcomes being in-hospital mortality, heart failure-related mortality, and atrial natriuretic peptide (ANP) levels at 24 h. Statistical analysis was performed using the Mantel-Haenszel

SUBMITTER: Khan A 

PROVIDER: S-EPMC12510218 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature